THE EFFECTS OF TCDD ON THE TRANSFORMATION AND MICRONUCLEUS FORMATION IN CHANG LIVER, HACAT AND MCF10A CELLS

  • Haikwan Jung (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Miyoung (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Miok Eom (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Hoil Kang (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Misun (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Seungwan Jee (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Taikyung Ryeom (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Hyeyoung Oh (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Okhee (Department of Special Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2001.05.01

Abstract

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin(TCDD), a prototype of many halogenated aromatic hydrocarbons, is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Despite extensive research, the mechanisms of TCDD-induced carcinogenesis are poorly understood, and its carcinogenic potential in human is not clear.(omitted)

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