Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.151-151
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- 2001
Oxidative DNA Damages and Its Repair Enzyme Acitivities in the SD rats by Repeated Inhalation Exposure to the Hexavalent Chromium
- Seung-Hee Maeng (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Il-Je Yu (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Hyun-Young Kim (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Cheol-Hong Lim (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Jong-Yoon Lee (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Kwon-seob Lee (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agenc) ;
- Yong-Mook Lee (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Ho-Keun Chung (Center for Occupational Toxicology, Occupational Safety ＆ Health Research Institute, Korea Occupational Safety ＆ Health Agency) ;
- Hai-Won Chung (School of Public Health, Seoul National University)
- Published : 2001.05.01
Abstract
According to the epidemiological studies in chromium workers, hexavalent chromium is associated with the risk of lung cancer. Reactive oxygen species produced by hexavalent chromium exposure may play an important role in the carcinogenesis process. We measured one kind of oxidative DNA damages, 8-hydroxydeoxyguanosine (8-OHdG) and its repair activities as an indicators of cellular oxidative stress in rat lungs by the repeated inhalation exposure to sodium chromate.(omitted)
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