한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

THE EFFECT OF FLUTAMIDE ON PUBERTY IN MALE RATS: AN EVALUATION OF THE PROTOCOL FOR THE ASSESSMENT OF PUBERTAL DEVELOPMENT AND THYROID FUNCTION

  • Shin, J.H. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Kim, H.S. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Moon, H.J. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Kang, I.H. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Kim, T.S. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Seok, J.H. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Kim, I.Y. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Nam, S.Y. (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, K.L. (Department of Toxicology, National Institute of Toxicological Research, KFDA) ;
  • Han, S.Y. (Department of Toxicology, National Institute of Toxicological Research, KFDA)
  • 발행 : 2001.05.01
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초록

To establish a test protocol for the rodent 20-day thyroid/pubertal assay, we dosed flutamide(fl), a non-steroidal androgen antagonist to intact male SD rats from postnatal day 33 for 20 days, and examined several reproductive endpoints for assessing the sensitivity of a list of parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

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