Involvement of p38 Mitogen-Activated Protein Kinase in the Cell Growth Inhibition by Sodium Arsenite

  • Park, Jung-A (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Kim, Ja-Young (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Kim, Tae-Hwan (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Yoo, Young-Do (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Yoo, Seong-Yul (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Cho, Chul-Koo (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Lee, Yun-Sil (Laboratory of Radiation Effect, Korea Cancer Center Hospital) ;
  • Lee, Su-Jae (Laboratory of Radiation Effect, Korea Cancer Center Hospital)
  • 발행 : 2001.05.01

초록

It is well known that p38 mitogen-activated protein kinase (p38MAPK) participates in cellular responses to mitogenic stimuli, environmental and genotoxic stresses, and apoptotic agents. Although there are several reports on p38MAPK in relation to cell growth and apoptosis, the exact mechanism of p38MAPK-mediated cell growth regulation remains obscure.(omitted)

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