한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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- Pages.127-127
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- 2001
RECLINICAL TOXICITY STUDY OF A NEW PHOSPHODIESTERASE-5 INHIBITOR (I) ACUTE TOXICITY STUDY AND MUTAGENICITY
- Kim, Dong-Hwan (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Hyeon Cho (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Kang, Kyung-Koo (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
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Ahn, Byoung-Ok
(Research Laboratories, Dong-A Pharm. Co., Ltd.)
;
- Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co., Ltd.)
- 발행 : 2001.05.01
초록
Single-dose toxicity of a new phosphodiesterse inhibitor-5, DA -8159, was studied in rats via oral and intravenous routes and in mice via oral route. In addition, genotoxic potential of DA-8159 was investigated by using of the battery of test; reverse mutation test on bacteria, chromosomal aberration test on cultured mammalian cells and micronucleous test on mice.(omitted)
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