Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.125-125
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- 2001
Aryl Hydrocarbon Receptor (AhR) -dependent Inhibition of AP-1 DNA binding by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in LPS-activated B cells
- Jaehong Suh (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
- Jeon, Young-Jin (Korea Research Institute of Bioscience and Biotechnology) ;
- Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology) ;
- Norbert E. Kaminski (Department of Pharmacology and Toxicology, Michigan State University) ;
- Yang, Kyu-Hwan (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
- Published : 2001.05.01
Abstract
B cell has been identified as the sensitive cellular target responsible for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced immune suppression. In isolated cell systems, the differentiation of B cells into antibody secreting plasma cells is believed to be inhibited by TCDD. We also have previously demonstrated IgM secretion was suppressed by TCDD in LPS-activated murine B cell line, CH12.LX.(omitted)
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