ORGANOPHOSPHATE-INDUCED BRAIN DAMAGE: NECROSIS, APOPTOSIS AND GFAP EXPRESSION

  • Kim, Yun-Bae (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
  • Hur, Gyeung-Baeng (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
  • Phi, Taek-San (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
  • Cheon, Ki-Cheol (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
  • Kim, Wang-Soo (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
  • Yeon, Gyu-Baek (Biomedical Section (GSDC-2-4), Agency for Defense Development)
  • 발행 : 2001.05.01

초록

The distribution of necrotic and apoptotic neural cells, and expression of astrocytic glial fibrillary acidic protein (GFAP) in the brain of rats poisoned intraperitoneally with diisopropylfluorophosphate were investigated. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were treated intramuscularly 30 min and 10 min, respectively, before diisopropylfluorophosphate (4 - 10 mg/kg) poisoning to reduce the mortality.(omitted)

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