한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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- Pages.121-121
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- 2001
Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression
- Lee, Jeong W. (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Ki D. Shin (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Shin W. Cha (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Kim, Jong-C. (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Kim, Eun J. (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Sang S. Han (Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Tae C. Jeong (College of Pharmacy, Yeungnam University) ;
- Woo S. Koh (Toxicology Research Center, Korea Research Institute of Chemical Technology)
- 발행 : 2001.05.01
초록
Thioacetamide has been known to cause immune suppression. In this report we studied the role of metabolic activation by flavin-containing monooxygenase in the thioacetamide-induced immune response. To determine whether the metabolites of thioacetamide produced by flavin-containing monooxygenase result in the immunosuppression, methimazole, a flavin-containing monooxygenase inhibitor, was used to block the flavin-containing monooxygenase pathway.(omitted)
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