Proceedings of the KSMRM Conference (대한자기공명의과학회:학술대회논문집)
- 2001.11a
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- Pages.172-172
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- 2001
Compensatory change of opposite hippocampus after temporal lobe surgery in patients with temporal lobe epilepsy Evidence from single-voxel proton MR spectroscopy
- Lee, Sang-Hyun (Departments of Diagnostic Radiology and Neurosurgery, Seoul National University College of Medicine) ;
- Chang, Kee-Hyun (Departments of Diagnostic Radiology and Neurosurgery, Seoul National University College of Medicine) ;
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Chung, Chun-Kee
(Departments of Diagnostic Radiology and Neurosurgery, Seoul National University College of Medicine) ;
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Song, In-Chan
(Departments of Diagnostic Radiology and Neurosurgery, Seoul National University College of Medicine) ;
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Han, Moon-Hee
(Departments of Diagnostic Radiology and Neurosurgery, Seoul National University College of Medicine)
- Published : 2001.11.01
Abstract
Purpose: To evaluate compensatory change of opposite hippocampus after temporal lobe surgery in th patient with temporal lobe epilepsy by using single-voxel proton MR spectroscopy. Method: Eighteen patients with intractable temporal lobe epilepsy (TLE) whose MR diagnos was unilateral hippocampal sclerosis (n=11) or localized unilateral anterior temporal lobe lesio (n=7) and who underwent anterior temporal lobectomy were included in the study. Singl proton MRS of opposite hippocampus was carried out on the same day or within 1 week af MR imaging before temporal lobe surgery and after over 1-year post-surgical follow-u Single voxel proton MRS were acquired using GE signa 1.5T scanner and spectrosco system (TR, 1500-2, 000: TE, 136-144). Region of interest (ROI) was placed in a simitar position for all examination to cover the medial temporal lobes including most of the head an body of hippocampus and a part of amygdala, the parahippocampal gyrus. The MR spectr were evaluated with a focus on the metabolite ratio of N-acetylaspartate (NAA choline-containing phospholipids (Cho), creatine (Cr). The metabolite ratios of NAA/ Cr were calculated from the relative peak height measurement. We evaluated change of th intensity ratio NAA/Cr between before and after surgery, to simplify quantification acro patients, because observed decreases in the ratio of NAA/Cr can be interpreted in terms o neuronal or axonal damage.
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