Reperfusion Hyperemia Demonstrated on Perfusion MRI: It′s Relationship with Programmed Cell Death

  • 이승구 (연세대학교 의과대학 진단방사선과학교실) ;
  • 김동익 (연세대학교 의과대학 진단방사선과학교실) ;
  • 김상흠 (연세대학교 의과대학 진단방사선과학교실) ;
  • 김시연 (연세대학교 의과대학 진단방사선과학교실) ;
  • 인연권 (연세대학교 의과대학 진단방사선과학교실)
  • 발행 : 2001.11.01

초록

Purpose: To evaluate the relationship between reperfusion hyperemia in reversible cerebral ischem and the degree of programmed cell death. Method: We produced the animal models of reversible cerebral ischemia in 10 cats by mean of middle cerebral artery (MCA) occlusion with transorbital approach. MCA was occluded b microvascular clamp for an hour. MR imaging was performed at 0, 1, 2 days after ischemi and reperfusion. Perfusion (PWI) [Contrast enhanced GRE EPI, TR/TE= 1500/40, 40 Phases, 128 matrix, 12 cm FOV] and diffusion (DWI) (SE EPI, b=0, 500, 1000) weighted images were obtained using Philips Intera 1.57 system. rCBV and ADC maps were calculated wi IDL based postprocessing program. Tissue slices were obtained after the last MR imagin TUNEL, Calbin and Acid-Fuscin staining were done for corresponding slices as MR imagin We investigated the differences of degree of apoptosis in the area of reperfusion hyperemia.

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