Proceedings of the KACD Conference (대한치과보존학회:학술대회논문집)

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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The effect of taurine and alendronate on the osteoclast differentiated by the sonicated extracts of Porphyromonas Gingivalis in vitro

  • Kim, Hyung-Su (Department of Conservative Dentistry, Yonsei University) ;
  • Lee, Seung-Jong (Department of Conservative Dentistry, Yonsei University) ;
  • Lee, Chan-Young (Department of Conservative Dentistry, Yonsei University) ;
  • Kum, Kee-Yeon (Department of Conservative Dentistry, Yonsei University)
  • Published : 2001.11.01
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Abstract

The objective of this study was to investigate the ability of alendronate and taurine in inhibiting in vitro osteoclast differentiation induced by bacteria. Whole cell sonicates of P. gingivalis were used as an osteoclast-stimulating factor in a mouse coculture system and differentiated osteoclasts were confirmed by tartrate-resistant acid phosphatase (TRAP) staining. Alendronate at the concentrations of 10-7, 10-6, and 10-5 M, and taurine at the concentrations of 4mM, 8mM, and 12mM were used.(omitted)

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