한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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- Pages.105-105
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- 2001
Studies on Proliferation and Migration of Glioma Cells for Development of an Artificial Nerve Tubing
- Hyun Song (College of pharmacy, Duksung Women′s University) ;
- Chung, Dong-June (Sungkyunkwan University) ;
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Choung, Pill-Hoon
(Seoul National University) ;
- Aree Moon (College of pharmacy, Duksung Women′s University)
- 발행 : 2001.11.01
초록
In an attempt to provide useful information on the development of an artifitial nerve tubing, proliferative and migrative properties of two glioma cell lines, C6 rat glioma cells and Hs683 human glioma cells, were examined. The present study shows that C6 cells proliferated more rapidly than Hs683 cells. The Hs683 cells are more adequate for the development of nerve tubing since unlike C6 cells, they are of human origin and known to be non-tumorigenic. In order to enhance proliferative and migrative abilities of Hs683 cells for the application as an artificial nerve tubing, we studied the effect of glial cell-derived neurotrophic factor (GDNF) on Hs683 cells. Cells were seeded in the scaffolds (polymer constructs), fabricated with type I collegen and alginate modified with cinnamoyl moiety, in the presence or absence of GDNF Stimulatory effect of GDNF on the proliferation and migration of Hs683 cells cultured in the scaffolds is currently under investigation. In addition, possible neuroprotective activities of natural products which inhibit staurosporine-induced apoptosis of glioma cells are also being studied.
키워드