한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2001년도 추계학술대회 및 정기총회
- /
- Pages.98-98
- /
- 2001
프로베네시드의 혈관 알파 수용체 길항 작용
Probenecid inhibit $\alpha$ -adrenergic receptor mediated vasoconstriction
- Kim, Sung-Jin (Department of Pharmacology, School of Dentistry, Kyung Hee University)
- 발행 : 2001.11.01
초록
It has been suggested that hyperuricemia is related to the development of essential hypertension. Hypertensive patients with hyperuricemia has decreased glomerular filtration activity as compared to normotensive patients with hyperuricemia. These studies indicates uric acid concentrations in blood is associated with hypertension, Probenecid is an uricosuric agent which decreases uric acid reabsorption at the proximal tubule. Recently, we have shown that probenecid exerts anti-hypertensive action in Spontaneously Hypertensive Rats. Considering these results, I have designed a series of experiments to explore potential mechanism of antihypertensive action, of probenecid. In isolated rat thoracic aorta. probenecid significantly prevented phenylephrine-induced contraction of the blood vessel. When endothelium removed blood vessels were used, probenecid produced same effect as the intact blood vessels, indicating that probenecid directly act through the
키워드