Influence of Cromakalim, a $K^{＋}$ Channel Opener, and Glibenclamide, a $K^{＋}$ Channel Blocker, on Intestinal Movements in Rabbit

토끼의 장운동에 미치는 $K^{＋}$ Channel 개방제인 Cromakalim과 $K^{＋}$ Channel 차단제인 Glibenclnmide의 영향

This study was attempted to investigate the effect of cromakalim(CRK). $K^{-}$ channel opener, and glibenclamide(GLY), $K^{-}$ channel blocker, on intestinal function of rabbit. CRK supressed the tension and spontaneous movement of intestinal strips. Such CRK strengthened the tension and spontaneous movement of strips potentiated by acetylcholine, whereas more attenuated those weakened by dopamine. GLY augmented the tension, did not affect to the spontaneous movement of strips. GLY inhibited the acetylcholine-potentiated responses of tension and spontaneous movements in intestinal strips. GLY blocked the weakened responses of tension, while did not affect to the dopamine-weakened responses of spontaneous movements in intestinal strips. The present studies suggest that $K^{-}$ channel opening suppresses intestinal movements, whereas it's blockade enhances intestinal movements in rabbit.abbit.