A Novel Photonuclease; Bromofluoroacetophenone Analogs

The photoinducible DNA cleaving activities of bromofluoroacetophenones as a novel photonuclease were investigated. The photolytic behavior and DNA cleaving acitivity of fluorine derivative were compared with those of non-fluorine substituted compound, 4'-bromoacetophenones. Although the DNA cleaving activities of fluorine analogs were similar with those of 4'-bromoacetophenones, ο-bromo-$\rho$-fluoro derivatives gave the better DNA cleaving activities than $\rho$-bromo-ο-fluoro derivatives did.