Effect of herbal medicine in Animal Models and Patients with Allergic Rhinitis

MBST at 4hr and SST at 3hr after oral administration remarkably inhibited histamine release from rat mast cells in a dose-dependent manner. MBST treated GPs failed to show biphasic phenomena which indicated to reduce nasal volume as leukotriene antagonists. Both groups of patients who took MBST and SST for 1 week or 2weeks showed significant decreased symptom severity index(SSI) from treatment week 2(p<0.05). The percent volume change after challenge of the antigen was decreased in patients took the extracts for tweets. We abstained longer suppression of the symptom than antihistamine.