대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Bioactive Metabolites from Selected Sponges of Korean and Tropical Waters

  • Shin, Jong-Heon (Marine Natural Products Laboratory, Korea Ocean Research Development Institute(KORDI)) ;
  • Park, Jung-Rae (Marine Natural Products Laboratory, Korea Ocean Research Development Institute(KORDI)) ;
  • Seo, Young-Wan (Marine Natural Products Laboratory, Korea Ocean Research Development Institute(KORDI)) ;
  • Lee, Hyi-Seung (Marine Natural Products Laboratory, Korea Ocean Research Development Institute(KORDI)) ;
  • Cho, Ki-Woong (Marine Natural Products Laboratory, Korea Ocean Research Development Institute(KORDI))
  • 발행 : 2001.04.01
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초록

Wondonins A and B, aromatic alkaloids of an unprecedented skeletal class have been isolated form and association of the sponges Poecillastra wondoensis and Jaspis sp. In addition, four novel bromotyrosine-derived metabolites, psammaplins $A_1$ and $A_2$, aplysinellins A and B, have been isolated from the tropical sponge Aplysinella rhax. The structures of these compounds have been determined on the basis of combined chemical and spectral analyses. The new compounds exhibited significant cytotoxicity and antiangiogenic activity as well as inhibitory activities against farnesyl protein transferase and leucine aminopeptidase. In addition to these compounds, several bioactive metabolites have been isolated from sponges of Korean and tropical waters.

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