한국수의병리학회:학술대회논문집 (Proceedings of the Korean Society of Veterinary Pathology Conference)
- 한국수의병리학회 2000년도 추계학술대회 및 정기총회
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- Pages.26-26
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- 2000
The Modifying Effect of Indole-3-Carbinol (I3C) in rat mammary carcinogenesis
- Kang, Jin-Seok (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administration) ;
- Nam, Ki-Taek (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
- Byeongwoo Ahn (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
- Park, Mi-Na (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
- Kim, Ki-Sok (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
- Jang, Dong-Deuk (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
- Kim, Dae-Joong (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administration)
- 발행 : 2000.09.01
초록
The consumption of cruciferous vegetables such as cabbage and broccoli have been shown to have a chemopreventive effect in human and in experimental animals. Indole-3-carbinol (I3C), one component of cruciferous vegetables, has been shown to exert its chemopreventive effect in liver, colon and mammary tissue before or concurrent exposure of carcinogen, but in some reports, there have been several evidence that consumption of I3C after carcinogen treatment induced tumor promotion in some tissues. There have been no reports about the effect of I3C after carcinogen exposure in N-Nitroso-N-methylurea (MNU)-induced mammary tumor model of rats. (omitted)
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