Selective Activation of Mitogen-Activated Protein (MAP) Kinase During the Progression of Renal Disease

  • Park, Sang-Joon (College of Veterinary Medicine, Kyungpook National University) ;
  • Jeong, Kyu-Shik (Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon Cit) ;
  • Jeong, Tae-Sook (Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon Cit) ;
  • Bok, Song-Hae (Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon Cit) ;
  • Lee, Cha-Soo (College of Veterinary Medicine, Kyungpook National University)
  • 발행 : 2000.09.01

초록

Most renal diseases progress by consecutive cell responses such as hypertrophy, hyperplsia, proliferation, defferentiation, sclerosis, fibrosis and other cellular degenerative process. These cellular responses are mediated by the activation of various mitogens such as vasoconstrictors, growth factors, hormone, genotoxins and cytokines through mechanical, hemodynamic, immunological injury as well as metabolic abnormality. (omitted)

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