Proceedings of the Korea Society of Poultry Science Conference (한국가금학회:학술대회논문집)

The Korean Society of Poultry Science (한국가금학회)
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Structure and Expression of the Chicken Myostatin Gene

  • Kim, Jin-Nam (School of Agricultural Biotechnology Seoul National University) ;
  • Moon, Je-Sung (School of Agricultural Biotechnology Seoul National Universty) ;
  • Lee, Eun-Young (School of Agricultural Biotechnology Seoul National Universty) ;
  • Hwang, Kyu-Choon (School of Agricultural Biotechnology Seoul National Universty) ;
  • Tae Hun (School of Agricultural Biotechnology Seoul National Universty) ;
  • Kim, Ki-Dong (School of Agricultural Biotechnology Seoul National Universty) ;
  • Han, Jae-Yong (School of Agricultural Biotechnology Seoul National Universty)
  • Published : 2000.11.01
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Abstract

A new murine TGF-$\beta$ family member, myostatin(growth/differentiation factor-8) is expressed specifically in developing and adult skeletal muscle and may be a negative regulator of skeletal muscle development. This study aims at characterization and identification of genomic organization of chicken myostatin gene. In thi study, we identified the genomic organization and sequence of chicken myostatin gene. Results of RT-PCR and Northern blots from various tissues showed different mRNA expression levels in developmental stages of chick embryos and demonstrated strong expression of myostatin mRNA in skeletal muscle. These facts suggest that chicken myostatin gene would play an important role not only in skeletal muscle cell but also in other tissues.

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