Dosimetry and MIRD for Re-188 Liquid Balloons
Re-188-DTPA 풍선 주위 선량분포와 의용내부피폭선량
- Lee, Dong-Soo (Departments of Nuclear Medicine, Seoul National University Hospital) ;
- Lee, Jin (Departments of Physics, Ewha Womans University)
- Published : 1999.05.21
Abstract
Re-188 is suitable for endovascular liquid-balloon brachytherapy for the prevention of restenosis after angioplasty. Re-188 was concentrated to 3700 MBq/ml and labeled with DTPA. According to dosimetric calculation, it took 420 seconds using Re-188 solution with concentration of 3700 MBq/ml to irradiate 17.6 Gy to the target at 1 mm from the balloon surface. Software was made to estimate the irradiation time. MIRD calculation with dynamic bladder model yielded the whole body dose of Re-188-DTPA as 0.005 mGy/MBq in case of balloon rupture and release of the whole amount into the blood.