Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 1999.06a
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- Pages.69-69
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- 1999
Differences of SRE (Serum Responsive Element) Activity and Gene Expression between AT5BIVA and LM217 Cells
- Park, Eun-Kyung (College of Medicine, Ulsan University) ;
- Kim, You-Jin (Asan Institute for Life Science) ;
- Rhee, Yun-Hee (Asan Institute for Life Science) ;
- Hyesook Chang (College of Medicine, Ulsan University) ;
- Park, Kun-Koo (Asan Institute for Life Sciences)
- Published : 1999.06.01
Abstract
The human genetic disorder ataxia-telangiectasia (A-T) is a multisystem disease characterized by extreme radiosensitivity. The recent identification of the gene mutated in A-T, ATM, and the demonstration that it encodes a homologous of phosphatidylinositol 3-kinase (PI3-K), the catalytic subunit of an enzyme involved in transmitting signals from the cell surface to the nucleus, provides support for a role for this gene in signal transduction.(omitted)
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