Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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인산화에 의한 사람심장 Voltage-gated $K^$통로 (hKv1.5) 활성 조절기전에 대한 전기생리학적 및 분자생물학적 접근

  • Kwak, Yong-Geun (Dept of Pharmacology, Chonbuk National Univ. Medical School) ;
  • Michael M. Tamkun (Depts of Physiol. and Biochem. and Mol. Biol., Colorado State Univ.)
  • Published : 1999.06.01
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Abstract

Voltage-gated $K^{＋}$ channels represent the most complex group of ion channel genes expressed in cardiovascular system. The human Kv1.5 channel (hKv1.5) represents the $I_{Kur}$ repolarizing current in atrial myocytes. The hKv1.5 channel is functionally modulated by the Kv$\beta$1.3 subunit, which converts it from a delayed rectifier to a channel with rapid inactivation and enhanced voltage sensitivity.(omitted)d)

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