Antioxidant Compounds from the Root Bark of Hibiscus syriacus

  • Lee, Sang-Jun (Korea Research Institute of Bioscience & Biotechnology) ;
  • Yun, Young-Sook (Korea Research Institute of Bioscience & Biotechnology) ;
  • Lee, In-Kyoung (Korea Research Institute of Bioscience & Biotechnology) ;
  • Ryoo, In-Ja (Korea Research Institute of Bioscience & Biotechnology) ;
  • Yun, Bong-Sik (Korea Research Institute of Bioscience & Biotechnology) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience & Biotechnology)
  • Published : 1999.10.01

Abstract

A new lignan named as hibiscuside, (+) pinoresinol 4-O-[-glucopyranosyl (12) -rhamnoside] (1), and a known lignan, syringaresinol (2) were isolated from the root bark of Hibiscus syriacus together with two feruloyltyramines (3,4) and three known isoflavonoids (5,6,7). The structures of these compounds have been established on the basis of their NMR, Mass, UV spectra. Among these phenolic compounds,6-O-acetyl daidzin (5), 6-O- acetyl genistin (6), and 3-hydroxy daidzein (7) with IC50 values of 8.2, 10.6, and 4.1 M, respectively, significantly inhibited lipid peroxidation in rat liver microsomes Hibiscuside (1), E and Z-N-feruloyl tyramines (3,4) exhibited moderate antioxidant activity.

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