Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 1999.10a
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- Pages.1-5
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- 1999
An Effective Antidandruff Agent - IPBC
- Shin, Moon-Sam (Pacific Research and Development Center, Yongin) ;
- Shin, Kye-Ho (Pacific Research and Development Center, Yongin) ;
- Suh, Kyung-Hee (Pacific Research and Development Center, Yongin) ;
- Suh, Sung-Hwan (Pacific Research and Development Center, Yongin) ;
- Lee, Oak-Seop (Pacific Research and Development Center, Yongin)
- Published : 1999.10.01
Abstract
The purpose of this study was to determine the effect of IPBC(3-lodo-2-propynylbutyl carbamate) on dandruff caused by the anthropophilic fungus Maiassezia furfur. The effects of IPBC on dandruff were examined by evaluating (a) the MIC value of IPBC using broth dilution method : (b) the remnant antimicrobial activity of IPBC containing shampoo on skin disc ; (c) the antidandruff efficacy of 1.0 % IPBC containing shampoo in double blind clinical trial. To investigate the remnant antimicrobial activity of IPBC against Maiassezia furfur, guinea pig-skin disc was washed with antidandruff shampoo and then the diameter of inhibition zone per disc was measured. For clinical trial, thirty healthy volunteers, aged 25-35, participated in 4 week study. At 0,2,4 weeks, examinations of scaling, itching on scalp were carried out. The MIC(Minimun Inhibition Concentration) values of IPBC range from 0.10 to 1.00