Analysis of Functional Connectivity in Human Working Memory using Positron Emission Tomography and Principal Component Analysis

  • Lee, J.S. (Interdisciplinary Program in Medical and Biological Engineering Major, Seoul National University) ;
  • Ahn, J.Y. (Department of Nuclear Medicine, Seoul National University) ;
  • Jang, M.J. (Department of Nuclear Medicine, Seoul National University) ;
  • Lee, D.S. (Department of Nuclear Medicine, Seoul National University) ;
  • Chung, J.K. (Department of Nuclear Medicine, Seoul National University) ;
  • Lee, M.C. (Department of Nuclear Medicine, Seoul National University) ;
  • Park, K.S. (Department of Biomedical Engineering, Seoul National University)
  • 이재성 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 안지영 (서울대학교 의과대학 핵의학교실) ;
  • 장명진 (서울대학교 의과대학 핵의학교실) ;
  • 이동수 (서울대학교 의과대학 핵의학교실) ;
  • 정준기 (서울대학교 의과대학 핵의학교실) ;
  • 이명철 (서울대학교 의과대학 핵의학교실) ;
  • 박광석 (서울대학교 의과대학 의공학교실)
  • Published : 1998.11.20

Abstract

To reveal the interconnected brain regions involved in human working memory, their functional connectivity was analyzed using principal component analysis (PCA). rCBF PET scans were peformed on 5 normal volunteers during the verbal and visual working memory tasks and PCA was applied. PCA produced the first principal components related with the increase of the difficulty and the second one which demonstrate the dissociation of verbal and visual memory system.

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