Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Synthesis, Properties and Permeation of Solutes through Hydrogels based on Poly(ethylene glycol)-co-Poly(lactones) diacrylate Macromers and Chitosan

UV 경화형 키토산/지방족 폴리에스터 Hydrogel IPN 제조 및 약물투과

  • Cho, S.M. (School of Chemical Engineering, College of Engineering, Hanyang University) ;
  • Kim, S.Y. (School of Chemical Engineering, College of Engineering, Hanyang University) ;
  • Lee, Y.M. (School of Chemical Engineering, College of Engineering, Hanyang University) ;
  • Sung, Y.K. (Department of Chemistry, Dongguk University) ;
  • Cho, C.S. (Department of Natural Fiber Science, College of Agriculture and Life Science, Seoul National University)
  • 조성민 (한양대학교 공과대학 공업화학과) ;
  • 김소연 (한양대학교 공과대학 공업화학과) ;
  • 이영무 (한양대학교 공과대학 공업화학과) ;
  • 성용길 (동국대학교 이과대학 화학과) ;
  • 조종수 (서울대학교 농업생명과학대학 천연섬유학과)
  • Published : 1998.11.20
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Abstract

Triblock copolymers from poly(ethylene glycol) (PEG) and D,L-lactide or $\varepsilon$-carprolactone were synthesized to prepare semi-interpenetrating polymer network (semi-IPN) with chitosan by U.V. irradiation method. Then, solute permeation through these semi-IPNs hydrogels were investigated. The structures of semi-IPNs were confirmed by FT-IR spectroscopy and wide angle X-ray diffractometer (WAXD). Equilibrium water content (EWC) of these hydrogels was in the range of 67-75%. The crystallinity, thermal properties and mechanical properties of semi-IPNs hydrogels were studied. All the hydrogels revealed a remarkable decrease in crystallinity as compared with PEG macromer itself. The tensile strengths of semi-IPNs hydrogels in dry state were rather high, but those of hydrogels in wet state decreased drastically. The permeabilities of solutes of hydrogels followed the swelling behaviors and were regulated by solute size.

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