대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)
- 대한의용생체공학회 1998년도 추계학술대회
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- Pages.72-73
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- 1998
이식형 혈당 센서의 생리활성 물질에 의한 방해 효과를 제거하기 위한 새로운 효소고정법 개발
Development of Enzyme Immobilization Method to Remove Interference by Physiological Chemicals for Implantable Glucose Sensors
- Chung, T.D. (Institute of Medical and Biological Engineering, Medical Research Center) ;
- Kim, H.C. (Department of Biomedical Engineering, Seoul National University)
- 발행 : 1998.11.20
초록
A new method for enzyme immobilization has been developed to remove interference by potential interferents in body fluids. Instead of using electron mediators, we chose direct hydrogen peroxide measurement route. Extremely hydrogen peroxide-selective polymer was coated as an inner membrane to exclude interferents and then glucose oxidase(GOx) was entrapped by electropolymerization of inert monomers. There was no solvent casting step throughout the whole fabrication procedure but all membranes on Pt-Ir electrode were formed by electropolymerization. Thus, membrane thickness, quantity of enzyme loaded and can be controlled by electrochemical parameters. As a result, reproducibility of biosensor characteristics becomes remarkably improved in terms of mass production.
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