Effects of Endothelin-1 on $Ca^{2+}$ Signaling in Guinea-Pig Ventricualr Myocytes: Role of Protein Kinase C

  • Woo, Sun-Hee (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Lee, Chin-Ok (Department of Life Sciences, Pohang University of Science and Technology)
  • 발행 : 1998.06.01

초록

Effects of endothelin-l (ET-l) on contraction, $Ca^{2+}$ transient and L -type $Ca^{2+}$ current ( $I_{Ca,L}$) were investigated in single ventricular myocytes isolated from guinea-pig hearts. ET-l at concentrations of 5 and 10 nM produced a biphasic pattern of inotropism: a first decrease in contraction by 34.4$\pm$2.5 % of the control followed by a sustained increase in contraction by 66.6$\pm$8.4% (mean$\pm$S.E.M., n=9).(omitted)

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