Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
권호 표지

Effects of Endothelin-1 on $Ca^{2+}$ Signaling in Guinea-Pig Ventricualr Myocytes： Role of Protein Kinase C

  • Woo, Sun-Hee (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Lee, Chin-Ok (Department of Life Sciences, Pohang University of Science and Technology)
  • Published : 1998.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Effects of endothelin-l (ET-l) on contraction, $Ca^{2＋}$ transient and L -type $Ca^{2＋}$ current ( $I_{Ca,L}$) were investigated in single ventricular myocytes isolated from guinea-pig hearts. ET-l at concentrations of 5 and 10 nM produced a biphasic pattern of inotropism： a first decrease in contraction by 34.4$\pm$2.5 ％ of the control followed by a sustained increase in contraction by 66.6$\pm$8.4% (mean$\pm$S.E.M., n=9).(omitted)

Keywords