Neurotensin Induces Catecholamine Secretion and Calcium Rise by B2 Bradykinin Receptor Activation in PC12 Cells

  • Park, Tae-Ju (Department of Life Science, Pohang University of Science and Technology (POSTECH)) ;
  • Kim, Kyong-Tai (Department of Life Science, Pohang University of Science and Technology (POSTECH))
  • Published : 1998.06.01

Abstract

The effect of neurotensin (NT) was investigated in rat pheochromocytoma (PC12) cells. When PC12 cells were treated with micromolar concentrations of NT, [$^3$H]norepinephrine ([$^3$H]NE) secretion and elevation of cytosolic Ca$\^$2+/ concentration ([Ca$\^$2+/]i) were evoked in a concentration-dependent manner with an EC$\sub$50/ of 50 ${\mu}$M.(omitted)

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