Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Effect of Single Amino Acid Replacements on the Folding of $\alpha_1$-Antitrypsin

  • Lee, Cheolju (Creative Research Initiatives, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yu, Myeong-Hee (Creative Research Initiatives, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1998.06.01
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Abstract

The effect of stabilizing single ammo acid replacements at the sites of Phe 51, Ala 70, and Met 374 on the folding of $\alpha$$_1$-antitrypsin was investigated by fluorescence spectroscopy. The residues Phe 51 and Met 374 are located in the hydrophobic core of the molecule, B $\beta$-sheet.(omitted)

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