Membrane Insertion of Cytochrome P450 1A2 Promoted by Anionic Phospholipids

  • Yun, Chul-Ho (Department of Biochemistry, Pai-Chai University)
  • Published : 1998.06.01

Abstract

The role of phospholipids in the membrane binding and subsequent insertion of the microsomal protein rabbit cytochrome P450 (P450) lA2 into phospholipid bilayers was investigated. The insertion of P450 lA2 into phospholipid bilayers was determined by the amount of quenching of Trp fluorescence of P450 lA2 by pyrene and brominated and doxyl-labeled phospholipids.(omitted)

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