Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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A Cyclitol Derivative as a Replication Inhibitor from the Marine Sponge Petrosia sp.

  • Lim, Young-Ja (RIDD, College of Pharmacy, Pusan National University) ;
  • Kim, Jung-Sun (RIDD, College of Pharmacy, Pusan National University) ;
  • Park, Jong-Hee (RIDD, College of Pharmacy, Pusan National University) ;
  • Im, Kwang-Sik (RIDD, College of Pharmacy, Pusan National University) ;
  • Kim, Dong-Kyoo (Dept. of Chemistry, Inje University) ;
  • Jongki Hong (Mass Spectrometry Group, Korea Basic Science Institute) ;
  • Jee H. Jung (RIDD, College of Pharmacy, Pusan National University)
  • Published : 1998.11.01
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Abstract

The marine sponge Petrosia sp. is known for various bioactive compounds including the recently reported polyacetylenic alcohols. In our continuous survey of bioactive compounds from the Petrosia sp. collected from Korean waters, a cyclopentanepentol which rarely occurs in natural products has been isolated. It was found to inhibit DNA replication at the initiation step.

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