Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1998.11a
- /
- Pages.167-168
- /
- 1998
Swainsonine Production in Tissue Culture of Swainsona species
- Calapardo, Marilou R. (National Institute of Molecular Biology and Biotechnology (BIOTECH) University of the Philippines Los Banos, College) ;
- McFarlane, Ian J. (School of Biochemistry and Molecular Genetics University of New South Wales)
- Published : 1998.11.01
Abstract
Swainsonine is a toxic indolizidine alkaloid found in the plant, Swainsona species (Dorling, 1978; Colgate, 1979). It is a potent inhibitor of the glycoprotein processing pathway in the Golgi apparatus. Specifically, it inhibits mannosicase II resulting in abherrant high mannose glycans. Recent studies showed that swainsonine prevents metastasis of tumor cells and it inhibits solid growth tumor, at least partially (Goss et al., 1994; Baptista et al, 1994).
Keywords