한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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- Pages.148-149
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- 1998
INFLUENCE OF PINACIDIL ON CATECHOLAMINE SECRETION EVOKED BY CHOLINERGIC STIMULATION AND MEMBRANE DEPOLARIZATION FROM THE RAT ADRENAL GLAND
- Lim, Dong-Yoon (Dep′t of Pharmacology, College of Medicine, Chosun University) ;
- Park, Geun-Hong (Dep′t of Pharmacology, College of Medicine, Chosun University) ;
- Choi, Cheol-Hee (Dep′t of Pharmacology, College of Medicine, Chosun University) ;
- Ko, Suk-Tai (College of Pharmacy, College of Pharmacy, Chosun University)
- 발행 : 1998.11.01
초록
It has been known that potassium channel openers are a new class of molecules that have attracted general interest because of their potent antihypertensive activity in vivo and vasorelaxant activity in vitro (Hamilton and Weston, 1989). In the present study, it was attempted to examine the effect of the potassium channel opener on catecholamine (CA) secretion evoked by cholinergic stimulation, membrane depolarization and calcium mobilization from the isolated perfused rat adrenal gland. The perfusion of pinacidil (30-300 uM) into an adrenal vein for 20 min produced relatively dose-dependent inhibition in CA secretion evoked by ACh (5.32 mM), high
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