Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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INFLUENCE OF TOTAL GINSENG SAPONIN ON NICOTINIC STIMULATION-INDUCED CATECHOLAMINE SECRETION FROM THE PERFUSED RAT ADRENAL GLAND

  • Lim, Dong-Yoon (Dep′t of Pharmacology, College of Medicine, Chosun University) ;
  • Choi, Hyeon (Dep′t of and Pharmacology, College of Medicine, Chosun University) ;
  • Hong, Soon-Pyo (Dep′t of Cardiology, College of Medicine, Chosun University) ;
  • Ko, Suk-Tai (Dep′t of Pharmacy, College of Medicine, Chosun University)
  • Published : 1998.11.01
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Abstract

The present study was designed to examine the effect of total ginseng saponin on CA secretion evoked by activation of nicotinic receptors from the isolated perfused rat adrenal glands. Total ginseng saponin given (100 $\mu\textrm{g}$/20 min) into an adrenal vein did fail to produce alteration of spontaneous CA release from the rat adrenal medulla. Acetylcholine (5.32 mM)- and DMPP (100 uM, a selective ncotinic receptor agonist)-evoked CA secretory responses were reduced markedly by the pretreatment with the total ginseng saponin at a rate of 100 $\mu\textrm{g}$/6.2 $m\ell$/20 min, respectively.

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