한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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- Pages.137-137
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- 1998
Stability, Efficacy, Absorption and Toxicity of a New Nasal Spray Formulation including Salmon Calcitonin
- Shim, Hyun-Joo (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Kim, Mi-Kyung (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Bae, En-Joo (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Lee, Eung-Doo (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Hyun Jo (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Kim, Soon-Hae (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co. Ltd,) ;
- Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd,)
- 발행 : 1998.11.01
초록
Stability, efficacy, absorption and toxicity of a new nasal spray formulation including salmon calcitonin were studied in the laboratory animals. After the effects of many excipients on the stability of salmon calcitonin were evaluated using HPLC system, we selected taurine. Our experimental composition of salmon calcitonin contains taurine as a stabilizer and HPMC (hydroxypropylmethyl cellulose) as an adhesive polymer. After intranasal administration of salmon calcitonin formulations, Mia
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