Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1998.11a
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- Pages.133-133
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- 1998
Novel Antibiotic Peptides, Tylopeptins A and B, from Tylopilus neofelleus: Isolation, Identification, and Biological Activity
- Lee, Sang-Jun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
- Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
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Cho, Duk-Hyun
(Department of Biology, Chonju Woosuk University) ;
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Yoo, Ick-Dong
(Korea Research Institute of Bioscience and Biotechnology (KRIBB))
- Published : 1998.11.01
Abstract
Tylopeptins A and B are novel peptides from methanol extract of fruit body of mushroom, Tylopilus neofelleus, These novel peptides were isolated by reverse-phase HPLC. And they have been shown to consist of one acetylated N -terminal residue, fourteen amino acids, and leucinol, C-terminal amino alcohol. Sequencial determination and complete 1H and 13C resonance assignments were based on positive ion F AB mass spectroscopy and two dimensional NMR techniques using HOHAHA, ROSEY, HMQC, and HMBC. These compounds are active against some Gram-positive bacteria, but inactive against phathogenic fungi and Gram-negative bacteria.
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