Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Antibacterial Compound against Pasteurella haemolytica is produced from Streptomyces sp. 51086

  • Kang, Hee-Chol (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • In- Ja Ryoo (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Yu, Seung-Hun (Department of agricultural biology, Chungnam National University) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
  • Published : 1998.11.01
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Abstract

The Pasteurella haemolytica-induced pneumonic lesions are frequently occurred with stress and infection of virus in the cattle. In the course of screening for antimicrobial activity against Pasteurella haemolytica, compound 51086 has been isolated from the fermentation broth of the strain streptomyces sp. The compound 51086 was purified by column chromatography and HPLC, subsequently. The structure of compound 51086 was determined as a hygromycin A by a combination of $^1$H NMR, $\^$l3/C NMR, HMBC, and ESI -MS. This compound showed significant antibacterial activity against P. haemolytica and P. multocidn in Gram-negative bacteria.

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