한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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- Pages.126-126
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- 1998
STRUCTURE, SYNTHESIS, AND BIOLOGICAL FUNCTION OF NATURAL PRODUCTS IN DEER ANTLER AND THEIR DERIVATIVES
- Kim, So-Yeon (Department of Chemistry, Ewha Womans University) ;
- Jhon, Gil-Ja (Department of Chemistry, Ewha Womans University) ;
- Lee, Yoon-Jin (Department of Chemistry, Ewha Womans University) ;
- Cho, So-Hye (Department of Chemistry, Ewha Womans University) ;
- Han, So-Yeop (Department of Chemistry, Ewha Womans University)
- 발행 : 1998.11.01
초록
Studies on natural products are of great interest, due to the limits in development of synthesized medicine and its side effects. Deer antler is the most popular cure-all type drug among Asian folk medicines. In this study, we newly isolated the biologically active components from chloroform extract and 70% ethanol extract of deer antler, and analyzed their structures. First, the structure of monoacetyldiglyceride in deer antler was identified. To investigate the structure-activity relationship of monoacetyldiglycerides, we synthesized diverse substituted glycerides from glycerol, and confirmed their structures by spectroscopic methods. Among seven structurally-interesting compounds tested in this study, compound 1,2,3,5, and 6 showed activity toward [Ca
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