EFFECTS OF SPIRAMINE ALKALOIDS ON THE PLATELET AGGREGATION

Spiraea japonica L. F., a plant species belongs to the Spiraea genus of Rosaceae family, has seven varieties. There are all varieties distributed in Yunnan province of China, and S. japonica var. acuminata and S. japonica var. fortunei were used as the folk medicines to treat malaria and inflammation etc.. Since 1960s, Japanese and Russian scholars obtained C$\_$20/-diterpenoid alkaloids from S. japonica L.F., also Chinese scholars got a series of Hetisine-type C$\_$20/-diterpenoid alkaloids from S. japonica var. fortunei in 1985. Since then, we started the chemical and pharmaceutical studies of this complex. Here we wish to report the bioactive effects of spiramine alkaloids and their derivatives on the platelet aggregation induced by AA, PAF, or ADP.