Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1998.05a
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- Pages.31-35
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- 1998
DESIGN AND SYNTHESES OF 2-OXIRANECARBOXYLATE DERIVATIVES AND THEIR HYPOGLYCEMIC ACTIVITIES
- Jew, Sang-sup (College of Pharmacy, Seoul National University) ;
- Kim, Eun-kyung (College of Pharmacy, Yeungnam University) ;
- Je, Sun-mi (College of Pharmacy, Yeungnam University) ;
- Zhao, Long-Xuan (College of Pharmacy, Yeungnam University) ;
- Kim, Hyung-ook (College of Pharmacy, Seoul National University) ;
- Park, Hyeung-geun (College of Pharmacy, Seoul National University) ;
-
Ko, Kwang-ho
(College of Pharmacy, Seoul National University)
;
- Kim, Won-ki (School of Medicine, Ewha Womans University) ;
- Kim, Hwa-Jung (College of Pharmacy, Ewha Womans University)
- Published : 1998.05.01
Abstract
A series of 2-oxiranecarboxylate derivatives was prepared as carnitine palmitoyl transferase I (CPT- -I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative, 15b showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir.
Keywords