Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Evaluation of Biostability of the Iron Oxide MRI Contrast Agent

산화철 조영제의 생체 안정성 평가

  • Moon, D.S. (Dept. of Biomedical Engineering Inje Univ.) ;
  • Kim, Y.K. (Dept. of Biomedical Engineering Inje Univ.) ;
  • Shin, S.H. (Dept. of Biomedical Engineering Inje Univ.) ;
  • Kwon, I.K. (Dept. of Biomedical Engineering Inje Univ.) ;
  • Kim, Y.H. (Korea Institute of Science and Technology(KIST)) ;
  • Seo, J.S. (Dept. of Radiology Yonsei Univ.) ;
  • Kim, M. (Kohap Cooperation)
  • 문덕수 (인제대학교 의용공학과) ;
  • 김영곤 (인제대학교 의용공학과) ;
  • 신승훈 (인제대학교 의용공학과) ;
  • 권일근 (인제대학교 의용공학과) ;
  • 김용희 (한국과학기술연구원) ;
  • 서진석 (연세대학교 진단방사선과) ;
  • 김만 (주식회사 고합 신소재 연구개발팀)
  • Published : 1997.05.23
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Abstract

Biostabilities of the iron oxide MRI contrast agent were evaluated using the cytotoxicity test and the animal test. Six experimental groups (35, 17, 5, 3.4, 1.7, 0.9 mg of iron oxide/10ml) and a control group were prepared for the cytotoxicity test. The cell count of higher concentration than 5 mg/10m1 become decrease significantly after 4-days incubation. Iron oxide was injected into the right vein of the two fully grown rabbits with the concentration of 0.5 or 0.9mg/kg of body weight respectively. Blood samples were collected and analyzed in turn after 30min, 1, 2, 4, 8, 16, 30, 60, 90days injection. The body temperature and weight of rabbits were measured simultaneously. The result of blood and serum analyses and the body temperature shows that there was no significant variation with respect to the sampling term and the dosage within this experimental conditions.

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