한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1997년도 춘계학술대회
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- Pages.108-108
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- 1997
The Effects of Nalbuphine on the Spontaneous locomotor activity and Primary Humoral Immune response in mice.
- Yun, Hee-Eun (College of Pharmacy, Sookmyung Women′s University) ;
- Kwak, Young-Hee (College of Pharmacy, Sookmyung Women′s University) ;
- Pyo, Myoung-Yun (College of Pharmacy, Sookmyung Women′s University)
- 발행 : 1997.04.01
초록
The effects of nalbuphine.HCI on the spontaneous locomotor activity and primary humoral immune response were investigated in ICR mice. Nalbuphine was intraperitoneally administered with the dose of 130, 260, 360 mg/kg in mice. The locomotor activity such as distance traveled was observed for 90min at 10min intervals. Nalbuphine showed the biphasic dose-response relationship on the spontaneous locomotor activity. IgM plaque forming cells(PFC) in splenocytes and IgM level in antiserum were significantly decreased depending on the dose of nalbuphine when nalbuphine was administered after the immunization, but slightly increased only at the low dose in the case of nabuphine administration after the immunization(SRBC).
키워드