한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1997년도 춘계학술대회
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- Pages.101-101
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- 1997
A novel cis/trans-diaminocyclohexane platinum coordination complexes possessing in vitro and in vivo antitumor activity
- Jung, Jee-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
- Chang, Sung-Goo (Department of Urology, School of Medicine, Kyung Hee University) ;
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Lee, Kyung-Tae
(College of Pharmacy, Kyung Hee University)
;
- Park, Young-Soo (College of Pharmacy, Kyung Hee University) ;
- Lee, Joo-Han (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.) ;
- Lee, Kyou-Heung (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.) ;
- Kim, Sang-Lin (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.)
- 발행 : 1997.04.01
초록
As part of a drug discovery program to develope more effective platinum-based anticancer drugs, a series of platinum complexes trans -diaminocyclohexane platinum bi sdiphenylphosphino -ethane (KHPC-002) cis-diaminocyclohexane platinum bisdiphenylphosphino-ethane (KHPC-006) has been evaluated in vitro against 4 human carcinoma cell lines with those of cisplatin using a tetrazolium-based colorimetric assay (MTT assay). The cell lines were two human bladder carcinoma cell lines, HT-1197 and HT-1376, human colon carcinoma cell line, HCT-116, and prostate cancer cell line DU-145.
키워드