대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)
- 대한의용생체공학회 1996년도 추계학술대회
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- Pages.327-330
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- 1996
Poly(L-leucine)/poly(ethylene oxide)/poly(L-leucine) triblock copolymers as wound dressing
- 발행 : 1996.11.15
초록
Poly(L-leucine)(PLL)/poly(ethylene oxide)(PEO)/poly (L-leucine)(PLL) block copolymers were synthsized by polymerization of L-leucine N-carboxyanhydride with diamine-terminated PEO for possibility of wound dressing which may have several advantages such as 1) increase of solubility, 2) control of biodegradation, 3) absorption of body fluid. 4) non-immunogenic effect than PLL homopolymer wound dressing aleady commercialized. Water content increased with an increase of PEO content in the block copolymer due to the hydrophilicity of PEO. Release of silver sulfadiazine(AgSD) from AgSD loaded wound dressing increased with an increase of PEO content in the block copolymer. It was found that the number of Pseudomonas aeruginosa decrease with an increase of PEO content due to the fast release of antibacterial agents with an increase of PEO content in the block copolymer.
키워드