대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)
- 대한의용생체공학회 1996년도 춘계학술대회
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- Pages.223-225
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- 1996
단백질흡착을 막는 소프트콘택트렌즈에 관한 연구
Study on protein adsorption resistant soft contact lens
- Jeong, Young-Il (Dept. of Polymer Engineering, Chonnam National University) ;
- Cho, Chong-Su (Dept. of Polymer Engineering, Chonnam National University) ;
- Na, Jae-Woon (Dept. of Polymer Science and Engineering, Sunchon National University) ;
- Kim, Sung-Ho (College of Pharmacy, Chosun University)
- 발행 : 1996.05.17
초록
Poly (ethylene glycol) (PEG)macromers terminated with acrylate groups and interpenetrating polymer networks(IPN) composed of poly(hydroxyethyl methacrylate)(PHEMA) or poly(hydroxyethyl methacrylate-co-hydropropyl methacrylate-co-N-vinyl pyrrolidone) [P(HEMA-co-HPMA-co-NVP)] and PEG macromer were synthesized with the aim of obtaining protein adsorption resisatnt soft contact lens. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Crosslinked P(HEMA) or P(HEMA-co-HPMA-co-NVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HWMA)/PEG IPN decreases with a decrease of molecular weight of PEG whereas its adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP)/PEG IPN decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEG macromer in the IPN preparation. There are also more adequate in the bioinertness and bioadhesion for the contact lens by P(HEMA)/PEG IPN or P(HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP).
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