한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
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PROTEIN-CROSS-LINKING BY METHYLGLYOXAL

  • Lee, Cheolju (Laboratory of Biophysics, Department of Microbiology, College of Natural Sciences, and Research Center for Molecular Microbiology, Seoul National University) ;
  • Kang, Sa-Ouk (Laboratory of Biophysics, Department of Microbiology, College of Natural Sciences, and Research Center for Molecular Microbiology, Seoul National University)
  • 발행 : 1996.07.01
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초록

To elucidate the mechanism for the cross-linking reaction in the glycation or Maillard reaction, we studied the reaction between proteins, and a three-carbon ${\alpha}$-ketoaldehyde, methylglyoxal. When Cu, Zn-SOD was incubated with 200 mM of methylglyoxal, the peroxidase activity as well as the superoxide dismutase activity was reduced. This reduction is accompanied by the decrease of the anion binding affinity of the enzyme. (omitted)

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