Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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$Ca^{2+}$ CALMODULIN CAUSES RAB3A TO DISSOCIATE FROM SYNAPTOSOMAL MEMBRANES

  • Park, Jae-Bong (Department of Biochemistry, Hallym University College of Medicine) ;
  • Christoper C. Farnsworth (Howard Hughes Medical Institute, Department of Biochemistry, University of Washington) ;
  • John A. Glomset (Howard Hughes Medical Institute, Department of Biochemistry, University of Washington)
  • Published : 1996.07.01
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Abstract

Rab3A is a synaptic vesicle-associated, GTP-binding protein that has been implicated in the regulation of neurotransmission. We show here that Ca2+/calmodulin can form a 1:1 complex with Rab3A and cause it to dissociate from synaptosomal membranes. Formation of the complex requires both the lipidated C-terminus of Rab3A and the presence of guanine nucleotide. (omitted)

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